CBL0137 - CAS 1197996-80-7

CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM) . It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.

P53, MDM-2/p53, NF-κB, Histone Acetyltransferase

Chromatin/Epigenetic, NF-κB, Apoptosis

1197909

0.9968

C21H24N2O2

336.43

C(CNC(C)C)N1C=2C(C=3C1=CC=C(C(C)=O)C3)=CC(C(C)=O)=CC2

-20°C

Ice Packs

Small Compound