CBR-5884 - CAS 681159-27-3

CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH

Dehydrogenase

Metabolism

681129

>99.99%

C14H12N2O4S2

336.39

CCOC(=O)c1sc(NC(=O)c2ccco2)c(SC#N)c1C

-20°C

Ice Packs

Small Compound