CbzNH-PEG4-CH2COOH - CAS 1451362-51-8

CbzNH-PEG4-CH2COOH is a PEG linker featuring a carboxylic acid (CO2H) group and a benzyloxycarbonyl (Cbz) protecting group. The hydrophilic PEG spacer enhances the compound's solubility in aqueous media. In the presence of activators such as HATU, the terminal carboxylic acid can react with primary amine groups to form stable amide bonds. The benzyloxycarbonyl protecting group can be removed through hydrogenolysis to yield a free amine.

1451362-51-8

C18H27NO8

385.409

O=C(O)COCCOCCOCCOCCNC(=O)OCC=1C=CC=CC1

-20°C

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