CC-647 - CAS 1061605-35-3

CC-647 is a molecular glue modulator targeting the Cereblon (CRBN) E3 ubiquitin ligase. It enhances the interaction between CRBN and ZBTB16, as well as its oncogenic fusion protein RARα-ZBTB16, with a half-maximal degradation concentration (DC50) of 103 nM for ZBTB16. CC-647 holds potential for studying ZBTB16-RARα related acute promyelocytic leukemia (APL) .

E1/E2/E3 Enzyme, Molecular Glues

PROTAC, Ubiquitination

1061567

C23H22N2O5

406.43

O=C1C=2C=CC=C(OC3=CC=CC(=C3)C(C)(C)C)C2C(=O)N1C4C(=O)NC(=O)CC4

-20°C

Ice Packs

PROTAC