CCR1 antagonist 12 - CAS 921208-19-7

CCR1 antagonist12 (Compound 12) is an antagonist of CCR1, exhibiting an IC50 of 3 nM against human CCR1. It inhibits the chemotaxis through pores induced by CCL3, with an IC50 of 0.009 μM. Additionally, CCR1 antagonist12 demonstrates favorable pharmacokinetic properties in a rat model.

CCR

Immunology/Inflammation, GPCR/G Protein, Microbiology/Virology

921208-19-7

C25H27ClFN3O4

487.95

O=C(C=CC1=CC(OC)=C(Cl)C=C1NC(=O)C)N2CC3N(CC4=CC=C(F)C=C4)C(COC3)C2

-20°C

Ice Packs

Small Compound