CCR4 antagonist 2 - CAS 2206788-99-8

CCR4 antagonist 2 (Compound 31) is a novel, potent, orally bioavailable small molecule antagonist of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+ flux and [chemotaxis] CTX at 40 nM and 70 nM, respectively.

Calcium Channel, CCR

Membrane transporter/Ion channel, GPCR/G Protein, Microbiology/Virology, Immunology/Inflammation, Metabolism

2206681

C26H28Cl2N6O

511.45

[C@H](C)(N1C=2C(C(C#N)=N1)=NC=C(N2)C=3C[C@@H](C)[C@H](CC3)N4[C@H](CO)CCC4)C5=C(Cl)C=C(Cl)C=C5

-20°C

Ice Packs

Small Compound