CCR4 antagonist 3-1 - CAS 1957-01-3

CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to CEM cell surface and inhibits TARC-mediated CEM cell migration in vitro with an IC50 value of 6.4 μM. CCR4 antagonist 3 inhibited the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to the CCR4 receptor on the surface of CEM cells and inhibited TARC-mediated migration of CEM cells in vitro with an IC50 value of 6.4 μM.

CCR

Immunology/Inflammation, GPCR/G Protein, Microbiology/Virology

1957-01-3

0.9987

C14H12N2S

240.32

N(C=1C2=C(C=CC1)C=CC=C2)C3=NC(C)=CS3

-20°C

Ice Packs

Small Compound