CCR4 antagonist 4 - CAS 668980-17-4

CCR4 Antagonist 4 (Compound 22) is a potent and selective antagonist of the CC chemokine receptor-4 (CCR4), displaying an IC50 value of 0.02 μM. It also inhibits MDC-mediated chemotaxis and Ca2+ mobilization, with IC50 values of 0.007 μM and 0.003 μM, respectively. This compound is utilized in research on allergic inflammation [1].

Others, CCR

Others, Immunology/Inflammation, GPCR/G Protein, Microbiology/Virology

668980-17-4

C24H27Cl2N7O

500.42

N(CC1=C(Cl)C=C(Cl)C=C1)C=2C3=C(N=C(N2)N4CCN(C(=O)[C@H]5CCCCN5)CC4)N=CC=C3

-20°C

Ice Packs

Small Compound