CCT128930 hydrochloride - CAS 2453324-32-6

CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50: 168 nM) through the targeting of Met282 of AKT, as well as 20-fold selectivity over p70S6K (IC50: 120 nM) .

Apoptosis, Akt, Autophagy, mTOR, PKA

Apoptosis, PI3K/Akt/mTOR signaling, Autophagy, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling

2453286

0.9975

C18H21Cl2N5

378.3

Cl.NC1(Cc2ccc(Cl)cc2)CCN(CC1)c1ncnc2[nH]ccc12

-20°C

Ice Packs

Small Compound