CCT241533 dihydrochloride - CAS 1962925-28-5

Potent Chk2 inhibitor (IC50 = 3 nM) . Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

Others, Chk

Others, Cell Cycle/Checkpoint

1962892

C23H29Cl2FN4O4

515.41

Cl.Cl.COc1cc2nc(nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC)-c1cc(F)ccc1O

-20°C

Ice Packs

Small Compound