CDD-2789 - CAS 3052084-77-9

CDD-2789 is a highly selective small molecule inhibitor that targets Activin receptor type 1 (ALK2, also known as ACVR1) . It effectively blocks the BMP and activin A-induced downstream phosphorylation reactions by inhibiting the ALK2/ALK1-mediated SMAD1/5 signaling pathway. In the NanoBRET cell model, CDD-2789 demonstrates an inhibitory activity with an IC50 value of 0.54 μM for ALK2. This compound holds potential for research in ALK2-related diseases, including brainstem glioma (DIPG), ependymoma, endometrial cancer, melanoma, non-small cell lung cancer, colorectal cancer, and pancreatic cancer.

TGF-beta/Smad, ALK

Angiogenesis, Stem Cells, Tyrosine Kinase/Adaptors

3051998

C26H34N4O4

466.573

O=C(NCCCN(C)C)C1=CC=C2N=C(C=3C=C(OC)C(OC)=C(OC)C3)N(C2=C1)C4CCC4

-20°C

Ice Packs

Small Compound