CDK/HDAC-IN-2 - CAS 2580938-58-3

CDK/HDAC-IN-2 is a potent dual HDAC/CDK inhibitor that acts on HDAC1 (IC50: 6.4 nM), HDAC2 (IC50: 0.25 nM), HDAC3 (IC50: 45 nM), HDAC6 and 8 (IC50 > 1000 nM), CDK1 (IC50: 8.63 nM), CDK2 (IC50: 0.30 nM), and CDK4, 6, and 7 (IC50 > 1000 nM) . CDK/HDAC-IN-2 can arrest the cell cycle in the G2/M phase and induce apoptosis, demonstrating excellent anti-proliferative and significant anti-tumor effects.

Others, Apoptosis, CDK, HDAC

Chromatin/Epigenetic, Others, DNA Damage/DNA Repair, Apoptosis, Cell Cycle/Checkpoint

2580877

C25H20Cl2N6O3

523.37

C(NCC1=CC=C(C(NC2=C(N)C=CC=C2)=O)C=C1)(=O)C=3C(NC(=O)C4=C(Cl)C=CC=C4Cl)=CNN3

-20°C

Ice Packs

Small Compound