CDK/HDAC-IN-3 - CAS 2944087-54-9

CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3, with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28 nM, and 82.87 nM, respectively, and is applicable in the treatment of acute myeloid leukemia (AML) [1].

HDAC, CDK

Chromatin/Epigenetic, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

2944024

C24H18Cl2N6O3

509.34

N(C(=O)C1=C(Cl)C=CC=C1Cl)C=2C(C(NC3=CC=C(C(NC4=C(N)C=CC=C4)=O)C=C3)=O)=NNC2

-20°C

Ice Packs

Small Compound