CDK-TCIP1 - CAS 3008612-35-6

CDK-TCIP1 is a bivalent molecule that links the CDK9 inhibitor SNS-032 with the BCL6 ligand BI3812. It effectively and specifically kills cells overexpressing BCL6, with an EC50 of 7.7 nM for SUDHL5 cells.

Bcl-2 Family, CDK

Cell Cycle/Checkpoint, Apoptosis

3008571

C48H62ClN11O8S2

1020.66

O=C1C(OCC(=O)NC)=CC=2C=C(C=C(OC)C2N1C)NC3=NC(=NC=C3Cl)N4CCC(C(=O)NCCCCCCC(=O)N5CCC(C(=O)NC6=NC=C(S6)SCC7=NC=C(O7)C(C)(C)C)CC5)CC4

-20°C

Ice Packs

Small Compound