CDK1/2/4-IN-1 - CAS 2414633-49-9

CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78, and 0.87 μM for CDK1, CDK2, and CDK4, respectively. It can be used in cancer research to arrest the cell cycle at the G2/M phase and induce apoptosis, elevating Bax, caspase-3, and P53 levels while decreasing Bcl-2 levels [1].

Others, Apoptosis, Caspase, Bcl-2 Family, CDK

Others, Proteases/Proteasome, Apoptosis, Cell Cycle/Checkpoint

2414575

C15H16N2O2S

288.36

C(/C=C/C1=CC=C(OC)C=C1)(=O)C=2N=C(NC)SC2C

-20°C

Ice Packs

Small Compound