CDK12-IN-6 - CAS 2651196-71-1

CDK12-IN-6, a pyrazolotriazine compound, is a powerful inhibitor of CDK12. Its inhibitory activity is significant with an IC50 value of 1.19 μM when tested at high ATP concentration (2 mM) . Notably, CDK12-IN-6 does not exhibit any inhibitory effect on CDK2/Cyclin E (IC50 >20 μM) and CDK9/Cyclin T1 (IC50 >20 μM) when tested under the same high ATP conditions (2 mM) (WO2021116178A1) .

CDK, Others

Others, Cell Cycle/Checkpoint

2651124

C20H21F2N9

425.448

Fc1ccc2nc(CNc3nc(nc4c(cnn34)C3CC3)N3CCNCC3)[nH]c2c1F

-20°C

Ice Packs

Small Compound