CDK12-IN-8 - CAS 2928619-86-5

CDK12-IN-8 (Compound Cpd143) is an orally active, highly selective inhibitor of cyclin-dependent kinase 12 (CDK12) . It blocks the phosphorylation of serine 2 in the C-terminal domain (CTD) of RNA polymerase II, thereby interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 holds potential for research in cancers with high CDK12 expression, such as small cell lung cancer and triple-negative breast cancer.

CDK

Cell Cycle/Checkpoint

2928528

C21H20F3N7O2

459.42

N([C@H]1C[C@@H](C=2N3C(=NN2)C=C(C#N)C=C3)CCC1)C=4N=C(OC5COC5)C(C(F)(F)F)=CN4

-20°C

Ice Packs

Small Compound