CDK2/9-IN-1 - CAS 2222285-23-4

CDK2/9-IN-1 (compound 20a) is an orally active dual inhibitor of CDK2 and CDK9, with IC50 values of 0.004 μM and 0.009 μM for CDK2 and CDK9, respectively. It induces apoptosis by regulating G2/M cell cycle arrest and exhibits antitumor activity.

Apoptosis, CDK

Apoptosis, Cell Cycle/Checkpoint

2222258

C14H14N6O2S2

362.43

O=S(=O)(N)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=NC=CS3)C

-20°C

Ice Packs

Small Compound