CDK4/6-IN-15 - CAS 2078047-99-9

CDK4/6-IN-15, an orally active and selective inhibitor of CDK4/6, effectively halts the growth of cancer cells by arresting the cell cycle at the G1 phase and inhibiting the phosphorylation of the retinoblastoma tumor suppressor protein (Rb) at S780, as well as suppressing E2 factor (E2F) -regulated gene expression.

Others, CDK

Others, Cell Cycle/Checkpoint

2077939

C21H27FN8S

442.56

CC1=C(SC(NC)=N1)C2=NC(NC3=CC=C(C=N3)N4CCC(N(C)C)CC4)=NC=C2F

-20°C

Ice Packs

Small Compound