CDK4/6-IN-17 - CAS 2035069-96-4

CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, exhibiting potent activity with IC50 values between 10-100 nM in BE (2) cells, and has demonstrated efficacy in inhibiting tumor growth in the COLO205 xenograft model [1].

CDK

Cell Cycle/Checkpoint

2034969

C27H28F4N8

540.56

C(F)(F)[C@H]1N2C=3C(N=C2CC1)=C(F)C=C(C3)C4=NC(NC5=CC=C(CN6CCN(CC)CC6)C=N5)=NC=C4F

-20°C

Ice Packs

Small Compound