CDK6/9-IN-2 - CAS 3068529-24-5

CDK6/9-IN-2 is a highly potent dual inhibitor of CDK6 (IC50 = 15 nM) and CDK9 (IC50 = 22 nM) with selectivity over CDK2, CDK8, and CDK11. It suppresses proliferation in IFN-γ/TNF-α-induced HaCaT cells and inhibits the STAT3 pathway and expression of inflammatory factors. CDK6/9-IN-2 alleviates psoriasis dermatitis and is applicable in psoriasis research.

CDK, Interleukin, STAT

Cell Cycle/Checkpoint, Immunology/Inflammation, Stem Cells, JAK/STAT signaling

3068500

C25H30ClN7O

480.01

O[C@@H]1CN(C2=CC=C(NC3=NC(NC4=CC=C(C=C4)N5CCN(C)CC5)=NC=C3Cl)C=C2)CC1

-20°C

Ice Packs

Small Compound