CDK6/PIM1-IN-1 - CAS 2677026-14-9

CDK6/PIM1-IN-1 is a balanced, potent dual inhibitor of CDK6 (IC50: 39 nM) and PIM1 (IC50: 88 nM), also showing inhibitory activity on CDK4 (IC50: 3.6 nM) . It significantly inhibits the proliferation of acute myeloid leukemia (AML) cells, arrests the cell cycle in G1 phase, induces cell apoptosis, and demonstrates anti-AML activity.

Others, Apoptosis, Pim, CDK

JAK/STAT signaling, Apoptosis, Chromatin/Epigenetic, Others, Cell Cycle/Checkpoint

2677003

C25H28FN9

473.55

N(CC)(CC)C1=NC2=C(C=CC(=C2)C3=NC(NC4=CC=C(C=N4)N5CCNCC5)=NC=C3F)N=C1

-20°C

Ice Packs

Small Compound