CDK7-IN-26 - CAS 3024545-79-4

CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 μM for inhibiting MDA-MB-453 cells in vitro.

CDK

Cell Cycle/Checkpoint

3024462

C22H22FN6OPS

468.49

N(C1=NC(=C2C(=N1)C=CS2)C=3C=4C(NC3)=C(P(C)(C)=O)C(C#N)=CC4)[C@H]5C[C@H](F)CNC5

-20°C

Ice Packs

Small Compound