CDK8-IN-12 - CAS 2613307-67-6

CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.

PKC, GSK-3, CDK

PI3K/Akt/mTOR signaling, Stem Cells, Cell Cycle/Checkpoint, Cytoskeletal Signaling, Chromatin/Epigenetic

2613234

0.9983

C21H20ClN3O2

381.86

O=C1C2(CCN(CC2)C=3C(=CN=CC3Cl)C4=CC=5C(O4)=CC=CC5)CCN1

-20°C

Ice Packs

Small Compound