CDK9/10/GSK3β-IN-1 - CAS 2423045-06-9

CDK9/10/GSK3β-IN-1 is a kinase inhibitor (Flavopiridol analogue) that effectively inhibits HsGSK3β, HsCDK9/CyclinT, HsCDK5/p25 and HsCDK2/CyclinA with IC50 values of 59 nM, 64 nM, 1.093 μM and 1.725 μM, respectively. CDK9/10/GSK3β-IN-1 exhibited comparable or higher anti-cancer cell activity than Flavopiridol and showed high anti-proliferative activity against up to seven cancer cell lines in vitro.

Others, CDK

Others, Cell Cycle/Checkpoint

2423045-06-9

C29H24ClN3O4S

546.04

OC=1C(=C2C(C(=O)C=C(O2)C3=C(Cl)C=C(SC=4N(C)C=5C(N4)=CC=CC5)C=C3)=C(O)C1)C=6CCN(C)CC6

-20°C

Ice Packs

Small Compound