CDKL5/GSK3-IN-1 - CAS 844442-32-6

CDKL5/GSK3-IN-1 (Compound 2) acts as a potent and selective chemical probe for CDKL5 and GSK3. It effectively inhibits CDKL5 and GSK3α/β with IC50 values of 4.6 nM for CDKL5, 24 nM for GSK3β, and 9.5 nM for GSK3α in NanoBRET assays. This compound is useful in the study of central nervous system disorders.

GSK-3

PI3K/Akt/mTOR signaling, Stem Cells

844404

C16H17F2N5O2

349.335

O=C(NC1=CNN=C1C(=O)NC2CCNCC2)C=3C=C(F)C=C(F)C3

-20°C

Ice Packs

Small Compound