CDPCP - CAS 106343-59-3

CDPCP is a platinum-containing DNA-crosslinking agent.1Unlike cisplatin or oxaliplatin , cDPCP forms monofunctional DNA adducts. It is transported into cells by organic cation transporter 1 (OCT1) and OCT2, inhibiting proliferation of MDCK cells expressing the human transporters with IC50values of 8.1 and 1.5 μM, respectively. cDPCP inhibits RNA polymerase II-mediated transcription in a reporter assay using HeLa cells. It increases survival in murine S180 sarcoma and P388 leukemia models when administered at doses of 40 and 80 mg/kg, respectively.2

Others

Others

106281

C5H7Cl2N3Pt

375.12

[Cl-].[NH][Pt++]([NH])([Cl-])[N]1=CC=CC=C1 |c:6,8,t:4,^1:1,3,4,5|

-20°C

Ice Packs

Small Compound