Cediranib - CAS 288383-20-0

Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit, selective more for VEGFR than PDGFR-α (36-fold), CSF-1R (110-fold), and Flt3 (1000-fold) in HUVEC cells.

C-Kit, PDGFR, FLT, VEGFR, Autophagy

Autophagy, Angiogenesis, Tyrosine Kinase/Adaptors

288363

0.9994

C25H27FN4O3

450.51

O(C=1C2=C(C=C(OCCCN3CCCC3)C(OC)=C2)N=CN1)C=4C(F)=C5C(=CC4)NC(C)=C5

-20°C

Ice Packs

Small Compound