Cenisertib - CAS 871357-89-0

Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well as kinase inhibitors of FER and its homolog. Cenisertib inhibits the growth of tumor mast cells (MCS) by inhibiting the activity of several different molecular targets. Cenisertib also inhibits tumor growth in pancreatic, breast, colon, ovarian and lung cancer and leukemia in xenograft models.

Aurora Kinase, STAT, FLT, Akt, Bcr-Abl

Chromatin/Epigenetic, Angiogenesis, JAK/STAT signaling, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Stem Cells

871268

C24H30FN7O

451.54

[H][C@@]12C[C@@]([H])(C=C1)[C@@H]([C@@H]2Nc1nc(Nc2ccc(N3CCN(C)CC3)c(C)c2)ncc1F)C(N)=O

-20°C

Ice Packs

Small Compound