CEP-14083 - CAS 856692-39-2

CEP-14083 is a potent ALK inhibitor that has shown activity in an NPM/ALK–carrying T-cell lymphoma in vitro study. Presumably, this compound binds to the hinge region of the kinase in an ATP-competitive manner. CEP-14083 displays a potent activity against ALK in enzymatic assays (IC50 = 11 nmol/L) . Further, CEP-14083 is also able to inhibit the insulin receptor at a concentration within a nanomolar range. In a preclinical assay, CEP-14083 showed that, via NPM/ALK TK inhibition, it could control the expression of molecules that determine T-cell identity and signaling in lymphoma cells. CEP-14083 has shown preclinical activity in both cell lines and animal models harboring ALK alteration.

Tie-2, Others, VEGFR, ALK, IGF-1R

Tyrosine Kinase/Adaptors, Angiogenesis, Others

856651

C31H30N6O2

518.61

C(CC)N1C=2C(=C3C(=C4C2CCC=5C4=CN(C)N5)C(=O)NC3)C=6C1=CC=C(NC(N(C)C7=CC=CC=C7)=O)C6

-20°C

Ice Packs

Small Compound