Ceralasertib formate - CAS 1352280-98-8

Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.

Others, ATM/ATR

Others, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair

1352174

C21H26N6O4S

458.54

OC=O.C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@](C)(=N)=O

-20°C

Ice Packs

Small Compound