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Ceritinib dihydrochloride - CAS 1380575-43-8

Ceritinib dihydrochloride - CAS 1380575-43-8

MF-0014788-01

$42.14 USD
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Product Details

  • Bioactivity

    Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase (IC50 of 200 pM) and also inhibits IGF-1R, InsR, and STK22D [IC50 values of 8, 7, and 23 nM, respectively], demonstrating significant antitumor potency.

  • Target

    ALK, IGF-1R

  • Related Pathways

    Tyrosine Kinase/Adaptors, Angiogenesis

  • CAS Number

    1380524

  • Purity

    0.9999

  • Molecular Formula

    C28H38Cl3N5O3S

  • Molecular Weight

    631.06

  • SMILES

    Cl.Cl.CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1

  • Storage Temperature

    -20°C

  • Shipping Conditions

    Ice Packs

  • Category

    Small Compound