CF53 - CAS 1808160-52-2

CF53 is a highly potent, selective, and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM, and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, being very selective over non-BET bromodomain-containing proteins. CF53 exhibits potent anti-tumor activity both in vitro and in vivo.

Epigenetic Reader Domain, Histone Acetyltransferase, CDK

Chromatin/Epigenetic, Cell Cycle/Checkpoint

1808106

>99.99%

C24H25N7O2

443.5

COc1cc2c(cc1-c1c(C)noc1C)[nH]c1nc(C)nc(Nc3cc(nn3C)C3CC3)c21

-20°C

Ice Packs

Small Compound