CFON-026 - CAS 2941611-57-8

CFON-026 is a selective, orally active, non-covalent BTK inhibitor with an IC50 of 0.27 nM. It demonstrates significant antitumor activity against wild-type BTK (TMD8 and REC-1) as well as all clinically relevant BTK resistance mutations (BTKC481S, T474I, L528W, and V416L) . CFON-026 induces complete tumor regression in the TMD8 xenograft mouse model. This compound is applicable for research into hematologic cancers, such as chronic lymphocytic leukemia and Waldenström's macroglobulinemia.

BTK

Tyrosine Kinase/Adaptors, Angiogenesis

2941546

C33H34N8O2

574.68

NC=1C=2N3C([C@]4(C[C@](NC(=O)CCCCC\C=C\C3=CN1)(CCC4)[H])[H])=NC2C5=CC=C(C(NC6=CC(C#N)=CC=N6)=O)C=C5

-20°C

Ice Packs

Small Compound