CGAS-IN-4 - CAS 2987886-49-5

CGAS-IN-4 (Compound 36) is an orally active inhibitor of cyclic GMP-AMP synthase (cGAS) with IC50 values of 32 nM for human cGAS (h-cGAS) and 5.8 nM for mouse cGAS (m-cGAS) . In THP-1 cells, cGAS-IN-4 inhibits cGAMP with an IC50 of 60 nM, enhancing cellular potency. Additionally, cGAS-IN-4 exhibits anti-inflammatory effects in a mouse model of Concanavalin A-induced acute liver injury.

CGAS

Immunology/Inflammation

2987832

C19H18Cl2N4O3

421.277

C[C@H]1C=2C=3C(NC2CCN1C(=O)C=4N=CC(OCCO)=CN4)=C(Cl)C(Cl)=CC3

-20°C

Ice Packs

Small Compound