CH5447240 - CAS 1253919-92-4

CH5447240 is an effective Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist for the treatment of Hypoparathyroidism. CH5447240 showed a potent in vitro hPTHR1 agonist effect (EC20: 3.0 nM; EC50: 12 nM) . It showed 55% oral bioavailability and a significantly elevated serum calcium level in hypocalcemic model rats.

Others, Thyroid hormone receptor (THR)

Endocrinology/Hormones, Others

1253919-92-4

C26H39N5O4S

517.68

O=C1C2(NC(=N1)[C@H]3CC[C@H](C)CC3)CCN(S(CCC4=C(C)C=C(N(C(N)=O)C)C=C4C)(=O)=O)CC2

-20°C

Ice Packs

Small Compound