CHD-1 - CAS 3041166-70-2

CHD-1 is a hypoxia-activated antitumor prodrug. It disrupts the mitochondrial morphology and membrane potential of hypoxic tumor cells, leading to excessive mitophagy and inducing apoptosis. In vitro, CHD-1 inhibits the growth of hypoxic tumor cells, while in vivo, it suppresses the growth of HeLa xenograft tumors.

Apoptosis, Mitophagy

Autophagy, Apoptosis

3041094

C16H12FNO4

301.269

C(/C=C/C1=CC(N(=O)=O)=CC=C1)(=O)C2=CC(F)=C(OC)C=C2

-20°C

Ice Packs

Small Compound