CHIR-99021 HCl - CAS 1797989-42-4

CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivity over CDC2, ERK2, and other protein kinases. Additionally, CHIR-99021 HCl serves as a robust activator of the Wnt/β-catenin signaling pathway. Moreover, it exhibits the ability to enhance self-renewal in both mouse and human embryonic stem cells. Furthermore, CHIR-99021 HCl induces autophagy [1] [2] [3].

GSK-3, Autophagy, Wnt/beta-catenin

PI3K/Akt/mTOR signaling, Stem Cells, Autophagy, Cytoskeletal Signaling

1797943

0.9844

C22H19Cl3N8

501.8

Cl.N#CC1=CN=C(C=C1)NCCNC=2N=CC(C3=NC=C(N3)C)=C(N2)C=4C=CC(Cl)=CC4Cl

-20°C

Ice Packs

Small Compound