Chlorido[N, N'-disalicylidene-1,2-phenylenediamine]iron (III) - CAS 39916-28-4

Chlorido[N, N'-disalicylidene-1,2-phenylenediamine]iron (III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N, N'-disalicylidene-1,2-phenylenediamine]iron (III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 μM, respectively), as well as NALM-6 cells resistant to daunorubicin and vincristine when used at concentrations ranging from 0.04 to 0.125 μM.2

Others, Ferroptosis, Reactive Oxygen Species

Apoptosis, Metabolism, NF-κB, Others, Immunology/Inflammation

39884

C20H14ClFeN2O2

405.64

[Cl-][Fe+3]123[O-]c4ccccc4C=[N]1c1ccccc1[N]2=Cc1ccccc1[O-]3 |c:10,21,^1:0,10,17|

-20°C

Ice Packs

Small Compound