CHMFL-ABL-053 - CAS 1808287-83-3

CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available inhibitor of BCR-ABL, SRC, and p38 kinases, with IC50 values of 70, 90, and 62 nM against ABL1, SRC, and p38, respectively. CHMFL-ABL-053 is a potentially useful drug candidate for Chronic Myeloid Leukemia (CML) [1].

Others, p38 MAPK, Bcr-Abl, Src

Cytoskeletal Signaling, Others, Angiogenesis, Tyrosine Kinase/Adaptors, MAPK

1808201

C28H26F3N7O2

549.55

N(C=1N=C(NC)C(C(NC2=CC(NC(=O)C3=CC(C(F)(F)F)=CC=C3)=CC=C2C)=O)=CN1)C4=CC(N)=C(C)C=C4

-20°C

Ice Packs

Small Compound