CHMFL-ABL/KIT-155 - CAS 2081093-21-0

CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM) . It arrests cell cycle progression and induces apoptosis.

Bcr-Abl, c-Kit, PDGFR, Discoidin Domain Receptor (DDR), Apoptosis

Apoptosis, Angiogenesis, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors

2081072

C33H38F3N5O3

609.68

C(C1=C(C(F)(F)F)C=C(C(NC2=CC(OC3CCN(C(=O)C=4C=CC(C)=NC4)CC3)=C(C)C=C2)=O)C=C1)N5CCN(C)CC5

-20°C

Ice Packs

Small Compound