Cho-Arg (trifluoroacetate salt) - CAS 1609010-56-1

Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It is cytotoxic to H1299 cells (IC50 = 88.5 μg/ml) .

Others, Liposome

Metabolism, Others

1608953

C43H71F6N5O7

884.059

OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC(=O)CCCCCNC(=O)[C@@H](N)CCCNC(N)=N)[C@H](C)CCCC(C)C |t:21|

-20°C

Ice Packs

Small Compound