Cholesterol 24-hydroxylase-IN-3 - CAS 1630746-27-8

Cholesterol24-hydroxylase-IN-3 is an orally bioavailable, selective, brain-penetrant CH24H inhibitor (IC50 = 23 nM), classified as a 1,3-oxazole derivative. It inhibits CH24H enzyme activity competitively by coordinating the 1,3-oxazole nitrogen atom with the heme iron, with the cyclopropyl group occupying a hydrophobic pocket. Cholesterol24-hydroxylase-IN-3 has potential applications in research on neurological disorders like epilepsy.

Cytochromes P450

Metabolism

1630711

C13H10F3N3O2

297.23

O=C(NC1=NC(=CC(=C1)C(F)(F)F)C=2OC=NC2)C3CC3

-20°C

Ice Packs

Small Compound