CHS-111 - CAS 886755-63-1

CHS-111 is a benzyl indazole compound that inhibits superoxide anion (O (2) (-) ) generation and reduces fMLP-stimulated PLD activity (IC (50) 3.9±1.2μM) . It inhibits the interaction of PLD1 with ADP-ribosylation factor (Arf) 6 and Ras homology (Rho) A, and reduces the membrane recruitment of RhoA in fMLP-stimulated cells.

Reactive Oxygen Species, Others

Others, NF-κB, Immunology/Inflammation, Metabolism

886691

C21H18N2O

314.38

C(N1C(=C2C(=N1)C=CC=C2)C3=CC=C(CO)C=C3)C4=CC=CC=C4

-20°C

Ice Packs

Small Compound