CI-898 HCl - CAS 1658520-97-8

CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR) . It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.

Parasite, DHFR, Others, Antifolate, DNA/RNA Synthesis, Antibiotic, Antibacterial

Cell Cycle/Checkpoint, Microbiology/Virology, Metabolism, Others, DNA Damage/DNA Repair

1658415

C19H26Cl3N5O3

478.8

Cl.Cl.Cl.COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC

-20°C

Ice Packs

Small Compound