CIB-L43 - CAS 1082942-70-8

CIB-L43 is a high affinity and orally available TRBP inhibitor (KD = 4.78 nM), which can effectively inhibit the biosynthesis of oncogenic miR-21, increase the expression of PTEN and Smad7, and block the AKT and TGF-β signaling pathways to inhibit the proliferation and migration of hepatocellular carcinoma (HCC) cells.

TGF-beta/Smad, PTEN, Akt, DNA/RNA Synthesis

Stem Cells, DNA Damage/DNA Repair, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint

1082864

0.9964

C15H16N2O3S

304.36

O=C(O)C=1SC(=NC1C)C=2C=CC(=CC2)N3CCOCC3

-20°C

Ice Packs

Small Compound