Ciprokiren - CAS 143631-62-3

Ciprokiren is a renin inhibitor discovered by Roche. Ciprokinen inhibited human renin in a buffer and human plasma with an IC50 of 0.07 and 0.65 nmol/L, respectively. In animal models, acute and chronic administration of ciprokinen lead to a reduction in arterial blood pressure. Development of ciprokinen was discontinued at a preclinical stage.

Others, RAAS

Endocrinology/Hormones, Others

143566

C37H55N5O8S

729.93

[C@@H](CC1=CN=CN1)(NC([C@H](CC2=CC=CC=C2)CS(C(C(=O)N3CCOCC3)(C)C)(=O)=O)=O)C(N[C@@H](CC4CCCCC4)[C@H]([C@@H](O)C5CC5)O)=O

-20°C

Ice Packs

Small Compound