Cisplatin - CAS 15663-27-1

Cisplatin (CDDP) is a chemotherapeutic agent with antitumor activity and is a classic DNA crosslinker. It inhibits DNA synthesis and induces DNA damage in cancer cells by forming DNA adducts, ultimately leading to cell death. In addition, Cisplatin can activate ferroptosis and induce autophagy. In animal studies, it is commonly used to establish models of chronic kidney injury and acute renal failure.

DNA/RNA Synthesis, Ferroptosis, DNA Alkylator/Crosslinker, Autophagy

Autophagy, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Apoptosis

15635

0.9963

Cl2H6N2Pt

300.04

N[Pt](Cl)(Cl)N

-20°C

Ice Packs

Small Compound