CJ-2360 - CAS 2226742-61-4

CJ-2360 is a potent, orally active ALK inhibitor, capable of acting on wild-type ALK (IC50: 2.2 nM) and F1197M (IC50: 4.0 nM), G1269A (IC50: 8.8 nM), L1196M (IC50: 6.3 nM) and S1206Y ALK mutant (IC50: 8.9 nM) . CJ-2360 strongly inhibited two clinically reported ALK mutants (C1156Y and L1196M) and 468 kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) .

Others, ALK

Others, Tyrosine Kinase/Adaptors, Angiogenesis

2226677

C27H30FN5O2

475.56

O=C1C2=C(N(C(C)C)C=3C1=CC(OC)=C(C3F)N4C[C@H](C)N(C)[C@H](C)C4)NC=5C2=CC=C(C#N)C5

-20°C

Ice Packs

Small Compound