CL385319 HCl - CAS 1210501-46-4

CL385319 is a potent inhibitor of H5N1 avian influenza A virus infection by blocking viral entry. CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2.54 μM. CL385319 with low cytotoxicity (CC50=1.48±0.01 mM) could also inhibit entry of pseudoviruses carrying hemagglutinins from H5N1 strains that were isolated from different places at different times, while it had no inhibitory activity on the entry of VSV-G pseudotyped particles.

Endogenous Metabolite, Others

Metabolism, Others

1210451

C15H19ClF4N2O

354.77

Cl.O=C(NCCN1CCCCC1)C2=CC(F)=CC(=C2)C(F)(F)F

-20°C

Ice Packs

Small Compound